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Raction affected calcusyn3/29/2024 ![]() ![]() Results: Our study is the first to report a significant positive correlation between G9a and Plk1 levels in 89 clinical samples of patients with CRC. Correlation between G9a and Plk1 expression was determined by analyzing clinical samples of patients with CRC by performing immunohistochemistry. Detailed molecular mechanisms underlying the effect of G9a on Plk1 expression were determined by performing point mutation analysis, chromatin immunoprecipitation analysis, and luciferase reporter assay. Methods: The role of Plk1 in G9a aberrant CRC was determined by performing different in vitro and in vivo assays, including assessment of cell growth by performing cell viability assay and assessment of signaling transduction profiles by performing immunoblotting, in the cases of pharmacological inhibition or short RNA interference-mediated suppression of G9a. Thus, we further characterized the detailed molecular mechanisms. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-like kinase 1 (Plk1) expression. Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. ![]() Select the file that you have just downloaded and select import option Reference Manager (RIS). Available fromĬlick on Go to download the file. G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1. Zhang J, Wang Y, Shen Y, He P, Ding J, Chen Y. ![]()
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